Tiangang Li, Ph.D.

Associate Professor of Physiology
Harold Hamm Chair for Adult Diabetes Research
Member, Harold Hamm Diabetes Center

Diabetes and non-alcoholic fatty liver disease (NAFLD) are closely associated with hepatic fat and cholesterol accumulation, hepatocyte organelle dysfunction, low grade inflammation, and dyslipidemia. Patients with diabetes and NAFLD have significantly higher risk of cardiovascular disease, which remains the leading cause of death worldwide. Bile acids are synthesized from cholesterol only in the liver. Hepatic bile acid synthesis is the only major cholesterol catabolic elimination mechanism in the body, and bile acids act as physiological detergents to facilitate dietary lipid and fat-soluble vitamin absorption in the small intestine. Furthermore, bile acids are signaling molecules that critically regulate metabolic homeostasis and inflammatory response by activating nuclear receptors and intracellular signaling pathways. Different therapeutic approaches targeting the bile acid signaling pathways have shown great promise for treating metabolic and chronic liver diseases including cholestasis, dyslipidemia, diabetes, and fatty liver disease. A major focus of the lab is to investigate how modulating the enterohepatic bile acid signaling impacts the complex metabolic network via distinct mechanism of actions. Through these studies, we hope to better understand the pathophysiological function of bile acids and to help establish the molecular basis for developing effective bile acid-based therapies. Current ongoing projects include:

  1. Bile acid signaling crosstalk with Transcriptional Factor EB (TFEB), a nutrient sensing master regulator of lysosomal biogenesis and autophagy, in the regulation of cholesterol and bile acid metabolism.
  2. Bile acid regulation of amino acid metabolism in control of hepatic glucose metabolism, insulin sensitivity and obesity development.
  3. Pharmacological modulation of hepatic insulin resistance in fatty liver disease.
  4. Bile acid signaling in aging-associated hepatic oxidative stress and drug-induced liver injury.

We address these questions by employing experimental mouse models through viral vector-mediated liver-specific gene delivery, tissue-specific genetic knockout, and pharmacological treatment approaches and a combination of physiological, molecular cell biology techniques and unbiased transcriptomics and metabolomics approaches.

Selected Publications:

Kim YC, Jung H, Seok S, Zhang Y, Ma J, Li T, Kemper B, Kemper JK. MicroRNA-210 promotes bile acid-induced cholestatic liver injury by targeting mixed-lineage leukemia-4 methyltransferase in mice. Hepatology. 2019 Sep 24;. doi: 10.1002/hep.30966. [Epub ahead of print] PubMed PMID: 31549733; NIHMSID:NIHMS1051596.

Ni HM, Chao X, Kaseff J, Deng F, Wang S, Shi YH, Li T, Ding WX, Jaeschke H. Receptor-Interacting Serine/Threonine-Protein Kinase 3 (RIPK3)-Mixed Lineage Kinase Domain-Like Protein (MLKL)-Mediated Necroptosis Contributes to Ischemia-Reperfusion Injury of Steatotic Livers. Am J Pathol. 2019 Jul;189(7):1363-1374. doi: 10.1016/j.ajpath.2019.03.010. Epub 2019 Apr 23. PubMed PMID: 31026418; PubMed Central PMCID: PMC6698941.

Machacek M, Saunders H, Zhang Z, Tan EP, Li J, Li T, Villar MT, Artigues A, Lydic T, Cork G, Slawson C, Fields PE. Elevated O-GlcNAcylation enhances pro-inflammatory Th17 function by altering the intracellular lipid microenvironment. J Biol Chem. 2019 May 31;294(22):8973-8990. doi: 10.1074/jbc.RA119.008373. Epub 2019 Apr 22. PubMed PMID: 31010828; PubMed Central PMCID: PMC6552434.

Khambu B, Li T, Yan S, Yu C, Chen X, Goheen M, Li Y, Lin J, Cummings OW, Lee YA, Friedman S, Dong Z, Feng GS, Wu S, Yin XM. Hepatic Autophagy Deficiency Compromises Farnesoid X Receptor Functionality and Causes Cholestatic Injury. Hepatology. 2019 May;69(5):2196-2213. doi: 10.1002/hep.30407. Epub 2019 Mar 8. PubMed PMID: 30520052; PubMed Central PMCID: PMC6461497.

Chen C, Li J, Matye DJ, Wang Y, Li T. Hepatocyte sortilin 1 knockout and treatment with a sortilin 1 inhibitor reduced plasma cholesterol in Western diet-fed mice. J Lipid Res. 2019 Mar;60(3):539-549. doi: 10.1194/jlr.M089789. Epub 2019 Jan 22. PubMed PMID: 30670473; PubMed Central PMCID: PMC6399493.

Chao X, Wang S, Zhao K, Li Y, Williams JA, Li T, Chavan H, Krishnamurthy P, He XC, Li L, Ballabio A, Ni HM, Ding WX. Impaired TFEB-Mediated Lysosome Biogenesis and Autophagy Promote Chronic Ethanol-Induced Liver Injury and Steatosis in Mice. Gastroenterology. 2018 Sep;155(3):865-879.e12. doi: 10.1053/j.gastro.2018.05.027. Epub 2018 May 18. PubMed PMID: 29782848; PubMed Central PMCID: PMC6120772.

Wang Y, Matye D, Nguyen N, Zhang Y, Li T. HNF4α Regulates CSAD to Couple Hepatic Taurine Production to Bile Acid Synthesis in Mice. Gene Expr. 2018 Aug 22;18(3):187-196. doi: 10.3727/105221618X15277685544442. Epub 2018 Jun 5. PubMed PMID: 29871716; PubMed Central PMCID: PMC6190117.

Li Y, Chao X, Yang L, Lu Q, Li T, Ding WX, Ni HM. Impaired Fasting-Induced Adaptive Lipid Droplet Biogenesis in Liver-Specific Atg5-Deficient Mouse Liver Is Mediated by Persistent Nuclear Factor-Like 2 Activation. Am J Pathol. 2018 Aug;188(8):1833-1846. doi: 10.1016/j.ajpath.2018.04.015. Epub 2018 May 25. PubMed PMID: 29803835; PubMed Central PMCID: PMC6099336.

Wang Y, Ding WX, Li T. Cholesterol and bile acid-mediated regulation of autophagy in fatty liver diseases and atherosclerosis. Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Jul;1863(7):726-733. doi: 10.1016/j.bbalip.2018.04.005. Epub 2018 Apr 10. Review. PubMed PMID: 29653253; PubMed Central PMCID: PMC6037329.

de Haan L, van der Lely SJ, Warps AK, Hofsink Q, Olthof PB, de Keijzer MJ, Lionarons DA, Mendes-Dias L, Bruinsma BG, Uygun K, Jaeschke H, Farrell GC, Teoh N, van Golen RF, Li T, Heger M. Post-hepatectomy liver regeneration in the context of bile acid homeostasis and the gut-liver signaling axis. J Clin Transl Res. 2018 May 28;4(1):1-46. doi: 10.18053/jctres.04.201801.001. Epub 2018 Feb 16. PubMed PMID: 30761355; PubMed Central PMCID: PMC6370335.

Wang Y, Li J, Matye D, Zhang Y, Dennis K, Ding WX, Li T. Bile acids regulate cysteine catabolism and glutathione regeneration to modulate hepatic sensitivity to oxidative injury. JCI Insight. 2018 Apr 19;3(8). doi: 10.1172/jci.insight.99676. eCollection 2018 Apr 19. PubMed PMID: 29669937; PubMed Central PMCID: PMC5931126.

Li J, Woolbright BL, Zhao W, Wang Y, Matye D, Hagenbuch B, Jaeschke H, Li T. Sortilin 1 Loss-of-Function Protects Against Cholestatic Liver Injury by Attenuating Hepatic Bile Acid Accumulation in Bile Duct Ligated Mice. Toxicol Sci. 2018 Jan 1;161(1):34-47. doi: 10.1093/toxsci/kfx078. PubMed PMID: 28453831; PubMed Central PMCID: PMC5837720.

Li J, Chen C, Li Y, Matye DJ, Wang Y, Ding WX, Li T. Inhibition of insulin/PI3K/AKT signaling decreases adipose Sortilin 1 in mice and 3T3-L1 adipocytes. Biochim Biophys Acta Mol Basis Dis. 2017 Nov;1863(11):2924-2933. doi: 10.1016/j.bbadis.2017.08.012. Epub 2017 Aug 24. PubMed PMID: 28844948; PubMed Central PMCID: PMC5659898.

Li J, Li T. Bile acid receptors link nutrient sensing to metabolic regulation. Liver Res. 2017 Jun;1(1):17-25. doi: 10.1016/j.livres.2017.04.001. Epub 2017 Apr 26. PubMed PMID: 29098111; PubMed Central PMCID: PMC5662125.

Li J, Matye DJ, Wang Y, Li T. Sortilin 1 knockout alters basal adipose glucose metabolism but not diet-induced obesity in mice. FEBS Lett. 2017 Apr;591(7):1018-1028. doi: 10.1002/1873-3468.12610. Epub 2017 Mar 16. PubMed PMID: 28236654; PubMed Central PMCID: PMC5423541.

Wang Y, Ding Y, Li J, Chavan H, Matye D, Ni HM, Chiang JY, Krishnamurthy P, Ding WX, Li T. Targeting the Enterohepatic Bile Acid Signaling Induces Hepatic Autophagy via a CYP7A1-AKT-mTOR Axis in Mice. Cell Mol Gastroenterol Hepatol. 2017 Mar;3(2):245-260. doi: 10.1016/j.jcmgh.2016.10.002. eCollection 2017 Mar. PubMed PMID: 28275691; PubMed Central PMCID: PMC5331786.

Li J, Wang Y, Matye DJ, Chavan H, Krishnamurthy P, Li F, Li T. Sortilin 1 Modulates Hepatic Cholesterol Lipotoxicity in Mice via Functional Interaction with Liver Carboxylesterase 1. J Biol Chem. 2017 Jan 6;292(1):146-160. doi: 10.1074/jbc.M116.762005. Epub 2016 Nov 23. PubMed PMID: 27881673; PubMed Central PMCID: PMC5217674.

Copple BL, Li T. Pharmacology of bile acid receptors: Evolution of bile acids from simple detergents to complex signaling molecules. Pharmacol Res. 2016 Feb;104:9-21. doi: 10.1016/j.phrs.2015.12.007. Epub 2015 Dec 17. Review. PubMed PMID: 26706784; PubMed Central PMCID: PMC4900180.

Li T, Apte U. Bile Acid Metabolism and Signaling in Cholestasis, Inflammation, and Cancer. Adv Pharmacol. 2015;74:263-302. doi: 10.1016/bs.apha.2015.04.003. Epub 2015 May 27. Review. PubMed PMID: 26233910; PubMed Central PMCID: PMC4615692.

Li J, Matye DJ, Li T. Insulin resistance induces posttranslational hepatic sortilin 1 degradation in mice. J Biol Chem. 2015 May 1;290(18):11526-36. doi: 10.1074/jbc.M115.641225. Epub 2015 Mar 23. PubMed PMID: 25805502; PubMed Central PMCID: PMC4416856.

Li T, Chiang JY. Bile acids as metabolic regulators. Curr Opin Gastroenterol. 2015 Mar;31(2):159-65. doi: 10.1097/MOG.0000000000000156. Review. PubMed PMID: 25584736; PubMed Central PMCID: PMC4332523.

Qi Y, Jiang C, Cheng J, Krausz KW, Li T, Ferrell JM, Gonzalez FJ, Chiang JY. Bile acid signaling in lipid metabolism: metabolomic and lipidomic analysis of lipid and bile acid markers linked to anti-obesity and anti-diabetes in mice. Biochim Biophys Acta. 2015 Jan;1851(1):19-29. doi: 10.1016/j.bbalip.2014.04.008. Epub 2014 May 4. PubMed PMID: 24796972; PubMed Central PMCID: PMC4219936.

Li T, Chiang JY. Bile acid signaling in metabolic disease and drug therapy. Pharmacol Rev. 2014 Oct;66(4):948-83. doi: 10.1124/pr.113.008201. Review. PubMed PMID: 25073467; PubMed Central PMCID: PMC4180336.

Li J, Bi L, Hulke M, Li T. Fish oil and fenofibrate prevented phosphorylation-dependent hepatic sortilin 1 degradation in Western diet-fed mice. J Biol Chem. 2014 Aug 8;289(32):22437-49. doi: 10.1074/jbc.M114.548933. Epub 2014 Jul 1. PubMed PMID: 24986865; PubMed Central PMCID: PMC4139250.

Li S, Hsu DD, Li B, Luo X, Alderson N, Qiao L, Ma L, Zhu HH, He Z, Suino-Powell K, Ji K, Li J, Shao J, Xu HE, Li T, Feng GS. Cytoplasmic tyrosine phosphatase Shp2 coordinates hepatic regulation of bile acid and FGF15/19 signaling to repress bile acid synthesis. Cell Metab. 2014 Aug 5;20(2):320-32. doi: 10.1016/j.cmet.2014.05.020. Epub 2014 Jun 26. PubMed PMID: 24981838; PubMed Central PMCID: PMC4365973.

Kim SC, Kim CK, Axe D, Cook A, Lee M, Li T, Smallwood N, Chiang JY, Hardwick JP, Moore DD, Lee YK. All-trans-retinoic acid ameliorates hepatic steatosis in mice by a novel transcriptional cascade. Hepatology. 2014 May;59(5):1750-60. doi: 10.1002/hep.26699. Epub 2014 Mar 26. PubMed PMID: 24038081; PubMed Central PMCID: PMC4008145.

Pathak P, Li T, Chiang JY. Retinoic acid-related orphan receptor α regulates diurnal rhythm and fasting induction of sterol 12α-hydroxylase in bile acid synthesis. J Biol Chem. 2013 Dec 27;288(52):37154-65. doi: 10.1074/jbc.M113.485987. Epub 2013 Nov 13. PubMed PMID: 24226095; PubMed Central PMCID: PMC3873570.

Bi L, Chiang JY, Ding WX, Dunn W, Roberts B, Li T. Saturated fatty acids activate ERK signaling to downregulate hepatic sortilin 1 in obese and diabetic mice. J Lipid Res. 2013 Oct;54(10):2754-62. doi: 10.1194/jlr.M039347. Epub 2013 Jul 31. PubMed PMID: 23904453; PubMed Central PMCID: PMC3770088.

Li T, Francl JM, Boehme S, Chiang JY. Regulation of cholesterol and bile acid homeostasis by the cholesterol 7α-hydroxylase/steroid response element-binding protein 2/microRNA-33a axis in mice. Hepatology. 2013 Sep;58(3):1111-21. doi: 10.1002/hep.26427. Epub 2013 Jul 31. PubMed PMID: 23536474; PubMed Central PMCID: PMC3735649.

Chanda D, Kim YH, Li T, Misra J, Kim DK, Kim JR, Kwon J, Jeong WI, Ahn SH, Park TS, Koo SH, Chiang JY, Lee CH, Choi HS. Hepatic cannabinoid receptor type 1 mediates alcohol-induced regulation of bile acid enzyme genes expression via CREBH. PLoS One. 2013;8(7):e68845. doi: 10.1371/journal.pone.0068845. Print 2013. PubMed PMID: 23894352; PubMed Central PMCID: PMC3718807.

Li T, Chiang JY. Nuclear receptors in bile acid metabolism. Drug Metab Rev. 2013 Feb;45(1):145-55. doi: 10.3109/03602532.2012.740048. Review. PubMed PMID: 23330546; PubMed Central PMCID: PMC3676171.

Kim YD, Li T, Ahn SW, Kim DK, Lee JM, Hwang SL, Kim YH, Lee CH, Lee IK, Chiang JY, Choi HS. Orphan nuclear receptor small heterodimer partner negatively regulates growth hormone-mediated induction of hepatic gluconeogenesis through inhibition of signal transducer and activator of transcription 5 (STAT5) transactivation. J Biol Chem. 2012 Oct 26;287(44):37098-108. doi: 10.1074/jbc.M112.339887. Epub 2012 Sep 12. PubMed PMID: 22977252; PubMed Central PMCID: PMC3481310.

Li T, Francl JM, Boehme S, Ochoa A, Zhang Y, Klaassen CD, Erickson SK, Chiang JY. Glucose and insulin induction of bile acid synthesis: mechanisms and implication in diabetes and obesity. J Biol Chem. 2012 Jan 13;287(3):1861-73. doi: 10.1074/jbc.M111.305789. Epub 2011 Dec 5. PubMed PMID: 22144677; PubMed Central PMCID: PMC3265867.

Li T, Chiang JY. Bile Acid signaling in liver metabolism and diseases. J Lipids. 2012;2012:754067. doi: 10.1155/2012/754067. Epub 2011 Oct 3. PubMed PMID: 21991404; PubMed Central PMCID: PMC3185234.

Misra J, Chanda D, Kim DK, Li T, Koo SH, Back SH, Chiang JY, Choi HS. Curcumin differentially regulates endoplasmic reticulum stress through transcriptional corepressor SMILE (small heterodimer partner-interacting leucine zipper protein)-mediated inhibition of CREBH (cAMP responsive element-binding protein H). J Biol Chem. 2011 Dec 9;286(49):41972-84. doi: 10.1074/jbc.M111.274514. Epub 2011 Oct 12. PubMed PMID: 21994947; PubMed Central PMCID: PMC3234973.

Chanda D, Kim DK, Li T, Kim YH, Koo SH, Lee CH, Chiang JY, Choi HS. Cannabinoid receptor type 1 (CB1R) signaling regulates hepatic gluconeogenesis via induction of endoplasmic reticulum-bound transcription factor cAMP-responsive element-binding protein H (CREBH) in primary hepatocytes. J Biol Chem. 2011 Aug 12;286(32):27971-9. doi: 10.1074/jbc.M111.224352. Epub 2011 Jun 21. PubMed PMID: 21693703; PubMed Central PMCID: PMC3151042.

Ge X, Yin L, Ma H, Li T, Chiang JY, Zhang Y. Aldo-keto reductase 1B7 is a target gene of FXR and regulates lipid and glucose homeostasis. J Lipid Res. 2011 Aug;52(8):1561-8. doi: 10.1194/jlr.M015859. Epub 2011 Jun 5. PubMed PMID: 21642744; PubMed Central PMCID: PMC3137022.

Li T, Matozel M, Boehme S, Kong B, Nilsson LM, Guo G, Ellis E, Chiang JY. Overexpression of cholesterol 7α-hydroxylase promotes hepatic bile acid synthesis and secretion and maintains cholesterol homeostasis. Hepatology. 2011 Mar;53(3):996-1006. doi: 10.1002/hep.24107. Epub 2011 Feb 11. PubMed PMID: 21319191; PubMed Central PMCID: PMC3079544.

Song KH, Li T, Owsley E, Chiang JY. A putative role of micro RNA in regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes. J Lipid Res. 2010 Aug;51(8):2223-33. doi: 10.1194/jlr.M004531. Epub 2010 Mar 29. PubMed PMID: 20351063; PubMed Central PMCID: PMC2903801.

Li T, Owsley E, Matozel M, Hsu P, Novak CM, Chiang JY. Transgenic expression of cholesterol 7alpha-hydroxylase in the liver prevents high-fat diet-induced obesity and insulin resistance in mice. Hepatology. 2010 Aug;52(2):678-90. doi: 10.1002/hep.23721. PubMed PMID: 20623580; PubMed Central PMCID: PMC3700412.

Han S, Li T, Ellis E, Strom S, Chiang JY. A novel bile acid-activated vitamin D receptor signaling in human hepatocytes. Mol Endocrinol. 2010 Jun;24(6):1151-64. doi: 10.1210/me.2009-0482. Epub 2010 Apr 6. PubMed PMID: 20371703; PubMed Central PMCID: PMC2875805.

Li T, Chanda D, Zhang Y, Choi HS, Chiang JY. Glucose stimulates cholesterol 7alpha-hydroxylase gene transcription in human hepatocytes. J Lipid Res. 2010 Apr;51(4):832-42. doi: 10.1194/jlr.M002782. Epub 2009 Oct 28. PubMed PMID: 19965590; PubMed Central PMCID: PMC2842145.

Chanda D, Li T, Song KH, Kim YH, Sim J, Lee CH, Chiang JY, Choi HS. Hepatocyte growth factor family negatively regulates hepatic gluconeogenesis via induction of orphan nuclear receptor small heterodimer partner in primary hepatocytes. J Biol Chem. 2009 Oct 16;284(42):28510-21. doi: 10.1074/jbc.M109.022244. Epub 2009 Aug 31. PubMed PMID: 19720831; PubMed Central PMCID: PMC2781394.

Li T, Ma H, Park YJ, Lee YK, Strom S, Moore DD, Chiang JY. Forkhead box transcription factor O1 inhibits cholesterol 7alpha-hydroxylase in human hepatocytes and in high fat diet-fed mice. Biochim Biophys Acta. 2009 Oct;1791(10):991-6. doi: 10.1016/j.bbalip.2009.05.004. Epub 2009 May 20. PubMed PMID: 19463968; PubMed Central PMCID: PMC2743791.

Li T, Chiang JY. Regulation of bile acid and cholesterol metabolism by PPARs. PPAR Res. 2009;2009:501739. doi: 10.1155/2009/501739. Epub 2009 Jul 14. PubMed PMID: 19636418; PubMed Central PMCID: PMC2712638.

Song KH, Li T, Owsley E, Strom S, Chiang JY. Bile acids activate fibroblast growth factor 19 signaling in human hepatocytes to inhibit cholesterol 7alpha-hydroxylase gene expression. Hepatology. 2009 Jan;49(1):297-305. doi: 10.1002/hep.22627. PubMed PMID: 19085950; PubMed Central PMCID: PMC2614454.

Li T, Ma H, Chiang JY. TGFbeta1, TNFalpha, and insulin signaling crosstalk in regulation of the rat cholesterol 7alpha-hydroxylase gene expression. J Lipid Res. 2008 Sep;49(9):1981-9. doi: 10.1194/jlr.M800140-JLR200. Epub 2008 May 29. PubMed PMID: 18511845; PubMed Central PMCID: PMC2515524.

Li T, Chiang JY. A novel role of transforming growth factor beta1 in transcriptional repression of human cholesterol 7alpha-hydroxylase gene. Gastroenterology. 2007 Nov;133(5):1660-9. doi: 10.1053/j.gastro.2007.08.042. Epub 2007 Aug 21. PubMed PMID: 17920062

Li T, Chen W, Chiang JY. PXR induces CYP27A1 and regulates cholesterol metabolism in the intestine. J Lipid Res. 2007 Feb;48(2):373-84. doi: 10.1194/jlr.M600282-JLR200. Epub 2006 Nov 6. PubMed PMID: 17088262; NIHMSID:NIHMS461941.

Li T, Kong X, Owsley E, Ellis E, Strom S, Chiang JY. Insulin regulation of cholesterol 7alpha-hydroxylase expression in human hepatocytes: roles of forkhead box O1 and sterol regulatory element-binding protein 1c. J Biol Chem. 2006 Sep 29;281(39):28745-54. doi: 10.1074/jbc.M605815200. Epub 2006 Aug 2. PubMed PMID: 16885156; PubMed Central PMCID: PMC1576296.

Li T, Jahan A, Chiang JY. Bile acids and cytokines inhibit the human cholesterol 7 alpha-hydroxylase gene via the JNK/c-jun pathway in human liver cells. Hepatology. 2006 Jun;43(6):1202-10. doi: 10.1002/hep.21183. PubMed PMID: 16729332; PubMed Central PMCID: PMC1526464.

Li T, Chiang JY. Rifampicin induction of CYP3A4 requires pregnane X receptor cross talk with hepatocyte nuclear factor 4alpha and coactivators, and suppression of small heterodimer partner gene expression. Drug Metab Dispos. 2006 May;34(5):756-64. doi: 10.1124/dmd.105.007575. Epub 2006 Feb 2. PubMed PMID: 16455805; PubMed Central PMCID: PMC1524881.

Song KH, Li T, Chiang JY. A Prospero-related homeodomain protein is a novel co-regulator of hepatocyte nuclear factor 4alpha that regulates the cholesterol 7alpha-hydroxylase gene. J Biol Chem. 2006 Apr 14;281(15):10081-8. doi: 10.1074/jbc.M513420200. Epub 2006 Feb 17. PubMed PMID: 16488887; PubMed Central PMCID: PMC1785292.

Li T, Chiang JY. Mechanism of rifampicin and pregnane X receptor inhibition of human cholesterol 7 alpha-hydroxylase gene transcription. Am J Physiol Gastrointest Liver Physiol. 2005 Jan;288(1):G74-84. doi: 10.1152/ajpgi.00258.2004. Epub 2004 Aug 26. PubMed PMID: 15331348; NIHMSID:NIHMS461935.

Targeting the Enterohepatic Bile Acid Signaling Induces Hepatic Autophagy via a CYP7A1–AKT–mTOR Axis in Mice. Cellular and molecular gastroenterology and hepatology. NIHMSID: NIHMS858534.