Assistant Professor, Harold Hamm Diabetes Center, Department of Physiology, OU Health Sciences Center
Dr. Lim earned her Ph.D. in Pathobiology from Columbia University in New York. She then pursued postdoctoral training at the Sanford Burnham Prebys Medical Discovery Institute in San Diego. Dr. Lim joined OUHSC as an Assistant Professor in 2016. Throughout her research career, Dr. Lim has discovered novel heart factors and delineated their molecular signaling mechanisms on cardiac physiology and energy metabolism. She was the first to uncover that reactive oxygen species (ROS) are produced under normal, non-stressed condition in the non-myocytes and critically mediate cellular cross-talks within the Drosophila heart. She also defined a previously-unrecognized phospholipid-SREBP signaling axis in the fly heart that is required for the maintenance of normal cardiac lipid homeostasis and proper heart function.
More recently, from large-scale genetic screens conducted in the lab, the Lim lab has identified genes with novel roles in the control of lipid and glucose metabolism, which include the Snail family genes and apoB-lipoprotein biosynthesis genes in the heart on lipid metabolism regulation and the transmembrane protein 214 (Tmem214) gene in the intestine on glucose metabolism regulation. Studies are currently ongoing to actively investigate the molecular mechanisms of action of these genes in their target tissues on the maintenance of energy homeostasis. In summary, the research conducted in the Lim lab using the efficient Drosophila model has led to the uncovering of new paradigms in the fields of cardiac biology and energy metabolism.