Shaoning Jiang, PhD

  • Position: Assistant Professor, Department of Pediatrics, Diabetes Research Member

Biography

Dr. Shaoning Jiang obtained her PhD degree in the Molecular and Cellular Pathology at the University of Alabama at Birmingham (UAB), and then received postdoctoral training at UAB and University of Oklahoma health Science Center (OUHSC).=

Dr.Jiang’s primary research goal is to understand the molecular mechanisms by which adverse maternal environments including diabetes mellitus and obesity impact placental/fetal mitochondrial and peroxisome biogenesis and function, and offspring long-term risk of metabolic diseases. She has been investigating the central roles of AMPK and epigenetic mechanisms by analyzing human cells and placental tissues of patients with diabetes and by using mouse models of maternal high fat diet.
Another ongoing project focuses on investigating the roles of miRNAs in regulating brown/beige adipogenesis and energy metabolism using transgenic mouse models.

Email

Shaoning-Jiang@ouhsc.edu

Additional Websites

Health Education
  • Graduate School
  • UAB, Pediatrics University of Oklahoma Health Sciences Center
    Oklahoma City, OK
  • Doctoral Studies University of Alabama at Birmingham
    Birmingham, AL
  • Medical Degree Peking University Health Science Center
    Peking, China,
Research Interests:
  • Epigenetic programming of mitochondrial biogenesis
  • Role of placental AMPK in mitochondrial homeostasis and oxidative stress during pregnancy
  • Brown/beige fat development and energy metabolism
  • Peroxisomes and fetal programming of NAFLD
Publications
  • Role of metformin in epigenetic regulation of placental mitochondrial biogenesis in maternal diabetes 2020

    Sci Rep. 2020 May 20;10(1):8314. doi:10.1038/s41598-020-65415-0. PMID: 32433500; PMCID: PMC7239922.

  • Fetal circulating human resistin increases in diabetes during pregnancy and impairs placental mitochondrial biogenesis 2020

    Mol Med. 2020 Aug 6;26(1):76. doi:10.1186/s10020-020-00205-y. PMID: 32762639; PMCID: PMC7409642.

  • Macrophage Derived MicroRNA-155 Increases in Obesity and Influences Adipocyte Metabolism by Targeting Peroxisome Proliferator-Activated Receptor Gamma 2019

    Obesity (Silver Spring). 2019 Nov;27(11):1856-1864. doi: 10.1002/oby.22616. Epub 2019 Sep 18.

  • Metformin reverses established lung fibrosis in a bleomycin model 2018

    Nature Medicine, 2018 Aug;24(8):1121-1127.

  • Role of microRNA-130b in placental PGC-1a/TFAM mitochondrial biogenesis pathway. Biochem Biophys Res Commun 2017

    2017 Jun 3;487(3):607-612.

  • Effects of maternal diabetes and fetal sex on human placenta mitochondrial biogenesis 2017

    Placenta, 2017 September; 57:26-32.

  • Influence of Gestational Diabetes Mellitus on Human Umbilical Vein Endothelial Cell microRNA 2016

    Clin Sci (Lond). 2016 Aug 25.